Epigenetic gene silencing in cancer

Epigenetic gene silencing in cancer.

Nickel and Epigenetic Gene Silencing

Insoluble nickel compounds are well-established human carcinogens. Occupational exposure to these compounds leads to increased incidence of lung and nasal cancer in nickel refinery workers. Apart from its weak mutagenic activity and hypoxia mimicking effect there is mounting experimental evidence indicating that epigenetic alteration plays an important role in nickel-induced carcinogenesis. Mul...

Epigenetic phenomena: Epigenetic phenomena: Paramutation and gene silencing in plants

Gene silencing is a widespread phenomenon in plants, and can affect endogenous genes as well as transgenes integrated into the genome [1,2]. Gene silencing can be induced by interactions between related genes, and one of the best-known examples is named paramutation. Paramutation is the directed heritable alteration of one allele following exposure to another allele in a heterozygote [3]. Examp...

epigenetic brca2 gene in epithelial ovarian cancer

background ovarian cancer is the most common fatal gynecologic malignancy in women. the brca2 gene has a role in regulation of cell cycle during proliferation, differentiation and dna repair. changes in the methylation of brca2 may be an effective mechanism for ovarian cancer. objectives the aim of the present study was to evaluate the association between ovarian cancer and methylation status o...

Epigenetic silencing of RELN in gastric cancer.

RELN (Reelin) is an extracellular glycoprotein that plays a critical role in neuronal migration. Here we show that the RELN gene is frequently silenced in gastric cancers (GCs) by aberrant promoter hypermethylation. Although RELN was strongly expressed in non-tumor gastric epithelia, its expression was weak, or absent, in GC cell lines and primary GC tumors. Absence of RELN expression significa...